Polymorphisms of MTHFR Associated with Higher Relapse/Death Ratio and Delayed Weekly MTX Administration in Pediatric Lymphoid Malignancies

Table 3

Outcome according to each genotype in all patients.

Gene	Locus or reference SNP ID		Patients number according to genotype	Relapsed/died of disease
MTHFR	C677T	CC	32	5
		CT/TT	70	8
			𝑃	0.540
MTHFR	A1298C	AA	67	13
		AC/CC	35	0
			𝑃	0.004
SLCO1B1	rs11045879	TT	42	6
		TC/CC	60	7
			𝑃	0.696
SLCO1B1	T521C	TT	73	8
		TC/CC	29	5
			𝑃	0.511
MTHFR	677CT/TT and 1298AA	no	18	0
		yes	53	8
			𝑃	0.105

All patients who had relapsed or died of disease had MTHFR c.1298AA genotype.