Table of Contents
Leukemia Research and Treatment
Volume 2013, Article ID 629283, 4 pages
http://dx.doi.org/10.1155/2013/629283
Clinical Study

Rapid Infusion Rituximab for Maintenance Therapy: Is It Feasible?

1Department of Pharmacy, H. Lee Moffitt Cancer Center, 12902 Magnolia Drive Tampa, FL 33612, USA
2Department of Malignant Hematology, H. Lee Moffitt Cancer Center, 12902 Magnolia Drive Tampa, FL 33612, USA

Received 11 July 2013; Accepted 28 August 2013

Academic Editor: Massimo Breccia

Copyright © 2013 Jolly Patel et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Rituximab is an anti-CD-20 monoclonal antibody used in the management of lymphoproliferative disorders. The use of maintenance rituximab has improved progression free survival and overall survival in follicular lymphomas. Although rapid rituximab infusions have been studied extensively, there is little data on the use of rapid infusions during maintenance therapy for low grade lymphomas. The primary objective of this retrospective analysis was to evaluate the incidence of Grade 3 and 4 toxicities with maintenance rapid infusion rituximab according to the Common Terminology Criteria for Adverse Events version 4 (CTC v. 4). Secondary objectives included evaluating all grade infusion related adverse events and correlation of adverse events with varying schedules of rituximab maintenance therapy. All patients who received rapid infusion rituximab as maintenance therapy for low grade lymphoma between December 2007 and November 2011 were included. Rapid rituximab infusions were administered over 90 minutes. Demographic, laboratory and clinical data were collected. A total of 109 patients received 647 rapid rituximab infusions. Three patients experienced an adverse reaction which resulted in one grade 1 infusion reaction and three grade 3 infusion reactions. No patients required hospitalization. All 3 patients received pharmacological and/or supportive care to relieve symptoms associated with the reaction.