A Novel Cryptic Three-Way Translocation t(2;9;18)(p23.2;p21.3;q21.33) with Deletion of Tumor Suppressor Genes in 9p21.3 and 13q14 in a T-Cell Acute Lymphoblastic Leukemia
Table 1
(a) Probes used for characterization of the three-way translocation, their location, and obtained results. (b) Probes used for characterization of the in aCGH detected deletions, their location, and obtained results.
(a)
Cytoband
Location hg19
Probe
Result for derivative chromosomes
2p24.3
chr2:
RP11-119F22
Signal on der(9); no split signal
16,014,784–16,140,647
2p23.3
chr2:
RP11-106G13
Signal on der(9); no split signal
26,967,697–27,136,688
2p23.2
chr2:
SPEC ALK
Signal on der(9); no split signal
29,415,640–29,447,593
9p22.1
chr9:
RP11-503K16
Signal on der(18); no split signal
18,717,972–18,718,524
9p22.1
chr9:
RP11-513M16
Signal on der(18); no split signal
19,371,384–19,371,943
9p21.3
chr9:
RP11-15P13
Signal on der(18); no split signal
20,182,493–20,361,132
9p21.3
chr9:
MLLT3
MLLT3-gene signal on der(18); no split signal
20,344,968–20,621,872
9p21.3
chr9:
SPEC p16
Deletion on der(9) and/or der(18)
21,967,751–21,975,132
9p21.3
chr9:
RP11-946B6
Deletion on der(9) and/or der(18) ish 9p21.3(RP11-946B6x0)[]
23,608,612–23,790,449
9p21.2
chr9:
RP11-438B23
Signal on der(9); no split signal
27,937,615–27,944,495
18q21.32
chr18:
MALT1
MALT1-gene signal on der(18); no split signal
56,338,618–56,417,370
18q21
chr18:
BCL2
BCL2-gene signal on der(2); no split signal
60,985,282–60,985,899
(b)
Cytoband
Location [hg19]
Probe
Result for derivative chromosomes
9p21.3
chr9: 21,967,751–21,975,132
SPEC p16
ish 9p21.3(p16x1)[] nuc ish 9p21(p16x0)[]/9p21(p16x1)[]/ 9p21(p16x2)[]
13q14.2
chr13: 48,920,000–49,140,000
LSI 13 = 1
nuc ish 13q14.2(1x0)[]/ 13q14.2(1x1)[]/ 13q14.2(1x2)[121]