Table of Contents
Leukemia Research and Treatment
Volume 2014, Article ID 592379, 4 pages
Clinical Study

Postinduction Supportive Care of Pediatric Acute Myelocytic Leukemia: Should Patients be Kept in the Hospital?

1Hurley Children’s Hospital and Hurley Medical Center, One Hurley Plaza, Flint, MI 48503, USA
2Department of Pediatrics/Human Development, Michigan State University College of Human Medicine, One Hurley Plaza, Flint, MI 48503, USA

Received 16 July 2014; Revised 14 September 2014; Accepted 15 September 2014; Published 29 September 2014

Academic Editor: Daniela Cilloni

Copyright © 2014 Susumu Inoue et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Children with AML become profoundly neutropenic while they undergo remission induction chemotherapy. It is unknown whether these children should be kept in the hospital while they are severely neutropenic to prevent life-threatening complications associated with neutropenia and reduce fatality. We at our institution routinely discharge patients after completing remission induction chemotherapy in the presence of profound neutropenia, unless it is clinically contraindicated. We reviewed all AML patients who were consecutively treated at our hospital from 1989 to 2011. Thirteen patients were electively discharged after completion of induction I chemotherapy. Of the 13, 4 died due to relapse or complications of stem cell transplants (not due to neutropenia related complications). Another eight are long term survivors. In this very small series, discharge from the hospital even though patients were severely neutropenic did not adversely affect the survival.