Metformin Induces Cell Cycle Arrest and Apoptosis in Drug-Resistant Leukemia Cells

Figure 1

Effect of metformin on leukemia cell viability. The leukemia cell lines CEM, 10E₁-CEM, and R5-CEM were exposed to metformin for the times and at the concentrations indicated, and cell viability was determined with the XTT assay. The values are shown relative to the untreated control cells (±SD) from at least three independent experiments performed in quadruplicate (): , statistically significant differences.

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