Metformin Induces Cell Cycle Arrest and Apoptosis in Drug-Resistant Leukemia Cells

Figure 3

The effect of metformin on the induction of autophagy. Western blots probed for LC3B in CEM and 10E₁-CEM cells exposed to metformin (10 mM) for the times indicated. Mel-Ho cells treated for 30 h with terfenadine (10 μM) were used as a positive control where conversion of LC3B-I isoform to the LC3B-II is shown.