Metformin Induces Cell Cycle Arrest and Apoptosis in Drug-Resistant Leukemia Cells

Figure 4

The effect of metformin on leukemia cell proliferation. CEM and 10E₁-CEM cells were treated with metformin (10 mM) for the times indicated and the viable cell number was determined as an arbitrary unit of absorbance after XTT tetrazolium salt incorporation. Values are represented as the cell number (±SD) relative to the controls of at least three independent experiments performed in quadruplicate (): , statistically significant differences.