Metformin Induces Cell Cycle Arrest and Apoptosis in Drug-Resistant Leukemia Cells

<div>Metformin induces cell cycle arrest. CCRF-CEM and 10E<sub>1</sub>-CEM cells were treated with 4 and 10 mM metformin for 72 h and cell cycle distribution was determined by flow cytometry. Representative histograms showing the distribution of cells on the basis of DNA content.</div>

Leukemia Research and Treatment

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Figure 5

Figure 5: Metformin Induces Cell Cycle Arrest and Apoptosis in Drug-Resistant Leukemia Cells 