Metformin Induces Cell Cycle Arrest and Apoptosis in Drug-Resistant Leukemia Cells

Figure 6

The effect of metformin on cell cycle regulatory proteins. Western blot analysis of cdc2 p34, cyclin A, cyclin B1, and cyclin E in CEM, 10E₁-CEM, and R5-CEM cells treated with metformin (10 mM) for the times indicated. Representative results of three independent assays performed are shown.