Metformin Induces Cell Cycle Arrest and Apoptosis in Drug-Resistant Leukemia Cells

Table 1

Apoptotic cell percentages after metformin treatment.

	Control	10 mM; 48 h	10 mM; 72 h
CEM
% viable cells	89.07 ± 1.82	89.39 ± 0.38	86.63 ± 0.43
% apoptotic cells	10.88 ± 1.86	10.38 ± 0.4	12.04 ± 1.7
10E1-CEM
% viable cells	91.49 ± 0.15	92.06 ± 0.04	40.39 ± 2.32
% apoptotic cells	8.40 ± 0.24	7.78 ± 0.6	58.61 ± 2.41

Induction of apoptosis was evaluated by flow cytometry of annexin V-PI labeled cells. Mean ± SD of three experiments is shown. for metformin versus control.