Metformin Induces Cell Cycle Arrest and Apoptosis in Drug-Resistant Leukemia Cells

Table 2

Cell cycle distribution analysis after metformin treatment.

	Control	4 mM	10 mM
CEM
G0/G1	63.87 ± 3.68	54.77 ± 2.63	52.98 ± 0.98
S	27.15 ± 1.48	29.44 ± 0.51	32.66 ± 3.53
G2/M	8.97 ± 2.46	15.79 ± 3.11	14.36 ± 3.72
S + G2/M	36.12 ± 3.67	45.23 ± 2.63	47.02 ± 0.98
10E1-CEM
G0/G1	68.55 ± 2.66	61.31 ± 0.95	49.41 ± 5.63
S	24.69 ± 0.76	32.39 ± 0.62	41.18 ± 6.58
G2/M	6.76 ± 2.51	6.29 ± 1.52	9.41 ± 0.95
S + G2/M	31.45 ± 2.66	38.68 ± 0.95	50.59 ± 5.63

Data are shown as cell percentages on different phases of the cell cycle and represent mean ± SD of three experiments. Differences between treatment and control were significant ().