Metformin Induces Cell Cycle Arrest and Apoptosis in Drug-Resistant Leukemia Cells

Table 4

Densitometric analysis of PKC and PKC levels.

	Control	24 h	48 h	72 h
CEM
PKC	1	0.76 ± 0.15	1.23 ± 0.03	0.89 ± 0.06
PKC	1	1.86 ± 0.58	1.28 ± 0.04	0.65 ± 0.08
10E1-CEM
PKC	1	0.96 ± 0.16	0.78 ± 0.18	0.87 ± 0.19
PKC	1	1.05 ± 0.66	0.53 ± 0.34	0.23 ± 0.08
R5-CEM
PKC	1	—	0.84 ± 0.35	0.36 ± 0.24
PKC	1	—	1.13 ± 0.01	2.08 ± 0.20

Data are expressed as fold changes compared with controls, normalized to actin, and represent mean ± SD of three experiments.