Research Article

Effectiveness and Cost-Effectiveness of Sequential Treatment of Patients with Chronic Myeloid Leukemia in the United States: A Decision Analysis

Table 3

Cost-effectiveness results base-case analysis.

Costs ($)Life yearsQALYsICERs ($/LY)ICURs ($/QALYs)

Chemo94,4924.863.47
Bosutinib → chemo/SCT676,2439.066.86Weakly dominatedWeakly dominated
Imatinib → chemo/SCT749,2729.617.29137,900171,700
Nilotinib → chemo/SCT884,22210.087.65Weakly dominatedWeakly dominated
Dasatinib → chemo/SCT912,36710.027.61DominatedDominated
Bosutinib → nilotinib → chemo/SCT913,6829.967.82DominatedWeakly dominated
Bosutinib → ponatinib → chemo/SCT947,1369.927.80DominatedDominated
Imatinib → nilotinib → chemo/SCT965,59710.448.14260,800253,500
Imatinib → ponatinib → chemo/SCT995,86810.408.12DominatedDominated
Imatinib → bosutinib → chemo/SCT1,020,85710.578.22Weakly dominatedWeakly dominated
Bosutinib → dasatinib → chemo/SCT1,062,22010.458.14DominatedDominated
Imatinib → dasatinib → chemo/SCT1,099,06510.888.43Weakly dominatedWeakly dominated
Nilotinib → ponatinib → chemo/SCT1,108,29110.808.39DominatedDominated
Dasatinib → nilotinib → chemo/SCT1,111,54910.798.38DominatedDominated
Nilotinib → bosutinib → chemo/SCT1,130,75010.958.48Weakly dominatedWeakly dominated
Dasatinib → ponatinib → chemo/SCT1,139,31410.758.35DominatedDominated
Dasatinib → bosutinib → chemo/SCT1,162,09210.908.45DominatedDominated
Nilotinib → dasatinib → chemo/SCT1,200,92111.238.67299,800445,100

Chemo: chemotherapy; ICERs: incremental cost-effectiveness ratios; ICURs: incremental cost-utility ratios; QALY: quality-adjusted life years; SCT: stem-cell transplantation.