Lymphoma / 2012 / Article / Fig 1

Research Article

Analysis of NF- B Pathway Proteins in Pediatric Hodgkin Lymphoma: Correlations with EBV Status and Clinical Outcome—A Children's Oncology Group Study

Figure 1

Classical and alternative NF- B pathway activation. (a) Activation of the classical NF- B pathway. Several receptors, including CD30, CD40, and LMP1, induce the classical NF- B pathway by activating the IKK complex. Phosphorylated IKK- phosphorylates I B- , inducing I B polyubiquitination and degradation by the 26S proteasome. Following I B degradation, NF- B dimerizes with NF- B1/p50 and translocates into the nucleus where gene transcription is activated. (b) Activation of the alternative NF- B pathway. The alternative NF- B pathway is activated by a restricted set of cell-surface receptors, including CD30, CD40, and the BAFF receptor. Alternative NF- B pathway activation increases the stability of NIK, which phosphorylates and activates IKK- . IKK- directly phosphorylates NF- B2/p100, inducing partial proteolysis of p100 to p52 by the 26S proteasome. The p52 NF- B subunit dimerizes with Rel-B and translocates into the nucleus, activating gene transcription. Proteins outlined in black were examined in the TMA. Cylindrical structure represents the 26S proteasome.
341629.fig.001a
(a) Classical   NF- B activation pathway
341629.fig.001b
(b) Alternative   NF- B activation pathway

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