Analysis of NF-B Pathway Proteins in Pediatric Hodgkin Lymphoma: Correlations with EBV Status and Clinical Outcome—A Children's Oncology Group Study
Examination of alternative NF-B pathway proteins in HL patients with a slow early response (SER) to therapy. (a) NIK expression in SER versus RER. Left panel: mean 2 standard deviations (95% confidence intervals) of NIK levels in RER versus SER. Significance was determined by the Wilcoxon rank-sum test. Middle and right panels: IHC from representative patients comparing NIK expression in an RER patient (middle panel) to an SER patient (right panel). (b) Alternative NF-B pathway in SER samples: scatter plot and linear regression analysis for cytoplasmic NIK (-axis) versus cytoplasmic IKK- (left panel), cytoplasmic NF-B2 (middle left panel), cytoplasmic Rel-B (middle right panel), and nuclear Rel-B (right panel). (c) Representative IHC from an SER patient samples immunostained with IKK- (left panel), NF-B2 (middle panel), and Rel-B (right panel). IHC pictures taken at 400 magnification using an Olympus BX41 microscope. Whole images were adjusted for contrast and brightness.
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