Lymphoma / 2012 / Article / Fig 5

Research Article

Analysis of NF- B Pathway Proteins in Pediatric Hodgkin Lymphoma: Correlations with EBV Status and Clinical Outcome—A Children's Oncology Group Study

Figure 5

Examination of alternative NF- B pathway proteins in HL patients with a slow early response (SER) to therapy. (a) NIK expression in SER versus RER. Left panel: mean 2 standard deviations (95% confidence intervals) of NIK levels in RER versus SER. Significance was determined by the Wilcoxon rank-sum test. Middle and right panels: IHC from representative patients comparing NIK expression in an RER patient (middle panel) to an SER patient (right panel). (b) Alternative NF- B pathway in SER samples: scatter plot and linear regression analysis for cytoplasmic NIK ( -axis) versus cytoplasmic IKK- (left panel), cytoplasmic NF- B2 (middle left panel), cytoplasmic Rel-B (middle right panel), and nuclear Rel-B (right panel). (c) Representative IHC from an SER patient samples immunostained with IKK- (left panel), NF- B2 (middle panel), and Rel-B (right panel). IHC pictures taken at 400 magnification using an Olympus BX41 microscope. Whole images were adjusted for contrast and brightness.

Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.