Table of Contents
Lymphoma
Volume 2013, Article ID 782903, 10 pages
http://dx.doi.org/10.1155/2013/782903
Research Article

Polo-Like Kinase 1: A Novel Target for the Treatment of Therapy-Resistant Mantle Cell Lymphoma

1Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, 986395 Nebraska Medical Center, Omaha, NE 68198-6395, USA
2Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198-7680, USA

Received 27 September 2012; Revised 29 November 2012; Accepted 16 December 2012

Academic Editor: Umberto Vitolo

Copyright © 2013 Adam K. Ahrens et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. F. Bertoni and M. Ponzoni, “The cellular origin of mantle cell lymphoma,” International Journal of Biochemistry and Cell Biology, vol. 39, no. 10, pp. 1747–1753, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. H. Nogai, B. Dörken, and G. Lenz, “Pathogenesis of non-Hodgkin's lymphoma,” Journal of Clinical Oncology, vol. 29, no. 14, pp. 1803–1811, 2011. View at Google Scholar
  3. P. Pérez-Galán, M. Dreyling, and A. Wiestner, “Mantle cell lymphoma: biology, pathogenesis, and the molecular basis of treatment in the genomic era,” Blood, vol. 117, no. 1, pp. 26–38, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. P. Jares, D. Colomer, and E. Campo, “Genetic and molecular pathogenesis of mantle cell lymphoma: perspectives for new targeted therapeutics,” Nature Reviews Cancer, vol. 7, no. 10, pp. 750–762, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. J. P. Leonard, M. E. Williams, A. Goy et al., “Mantle cell lymphoma: biological insights and treatment advances,” Clinical Lymphoma & Myeloma, vol. 9, no. 4, pp. 267–277, 2009. View at Google Scholar · View at Scopus
  6. M. E. Williams, M. Dreyling, J. Winter, S. Muneer, and J. P. Leonard, “Management of mantle cell lymphoma: key challenges and next steps,” Clinical Lymphoma, Myeloma and Leukemia, vol. 10, no. 5, pp. 336–346, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. M. Dreyling and W. Hiddemann, “Current treatment standards and emerging strategies in mantle cell lymphoma,” Hematology, pp. 542–551, 2009. View at Google Scholar · View at Scopus
  8. M. Ghielmini and E. Zucca, “How I treat mantle cell lymphoma,” Blood, vol. 114, no. 8, pp. 1469–1476, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. A. M. Gianni, M. Magni, M. Martelli et al., “Long-term remission in mantle cell lymphoma following high-dose sequential chemotherapy and in vivo rituximab-purged stem cell autografting (R-HDS regimen),” Blood, vol. 102, no. 2, pp. 749–755, 2003. View at Publisher · View at Google Scholar · View at Scopus
  10. E. Jacobsen and A. Freedman, “An update on the role of high-dose therapy with autologous or allogeneic stem cell transplantation in mantle cell lymphoma,” Current Opinion in Oncology, vol. 16, no. 2, pp. 106–113, 2004. View at Publisher · View at Google Scholar · View at Scopus
  11. A. K. Ahrens, N. K. Chaturvedi, T. M. Nordgren, B. J. Dave, and S. S. Joshi, “Establishment and characterization of therapy-resistant mantle cell lymphoma cell lines derived from different tissue sites,” Leukemia & Lymphoma, vol. 53, no. 11, pp. 2269–2278, 2012. View at Publisher · View at Google Scholar
  12. G. V. Hegde, T. M. Nordgren, C. M. Munger, A. K. Mittal, P. J. Bierman, D. D. Weisenburger et al., “Novel therapy for therapy-resistant mantle cell lymphoma: multipronged approach with targeting of hedgehog signaling,” International Journal of Cancer, vol. 131, no. 12, pp. 2951–2960, 2012. View at Google Scholar
  13. F. Barr, H. Sillje, and E. Nigg, “Polo-like kinases and the orchestration of cell division,” Nature Reviews Molecular Cell Biology, vol. 5, pp. 429–440, 2004. View at Google Scholar
  14. K. Strebhardt and A. Ullrich, “Targeting polo-like kinase 1 for cancer therapy,” Nature Reviews Cancer, vol. 6, no. 4, pp. 321–330, 2006. View at Publisher · View at Google Scholar · View at Scopus
  15. F. Eckerdt, J. Yuan, and K. Strebhardt, “Polo-like kinases and oncogenesis,” Oncogene, vol. 24, no. 2, pp. 267–276, 2005. View at Publisher · View at Google Scholar · View at Scopus
  16. A. Ahr, T. Karn, C. Solbach et al., “Identification of high risk breast-cancer patients by gene expression profiling,” The Lancet, vol. 359, no. 9301, pp. 131–132, 2002. View at Publisher · View at Google Scholar · View at Scopus
  17. M. Petronczki, P. Lénárt, and J. M. Peters, “Polo on the rise-from mitotic entry to cytokinesis with Plk1,” Developmental Cell, vol. 14, no. 5, pp. 646–659, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. V. Archambault and D. Glover, “Polo-like kinases: conservation and divergence in their functions and regulation,” Nature Reviews Molecular Cell Biology, vol. 10, no. 4, pp. 265–275, 2009. View at Google Scholar
  19. S. M. A. Lens, E. E. Voest, and R. H. Medema, “Shared and separate functions of polo-like kinases and aurora kinases in cancer,” Nature Reviews Cancer, vol. 10, no. 12, pp. 825–841, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. B. Fenton and D. M. Glover, “A conserved mitotic kinase active at late anaphase-telophase in syncytial Drosophila embryos,” Nature, vol. 363, no. 6430, pp. 637–640, 1993. View at Publisher · View at Google Scholar · View at Scopus
  21. D. M. Glover, I. M. Hagan, and A. Tavares, “Polo-like kinases: a team that plays throughout mitosis,” Genes and Development, vol. 12, no. 24, pp. 3777–3787, 1998. View at Google Scholar · View at Scopus
  22. F. J. Clay, S. J. McEwen, I. Bertoncello, A. F. Wilks, and A. R. Dunn, “Identification and cloning of a protein kinase-encoding mouse gene, Plk, related to the polo gene of Drosophila,” Proceedings of the National Academy of Sciences of the United States of America, vol. 90, no. 11, pp. 4882–4886, 1993. View at Google Scholar · View at Scopus
  23. U. Holtrich, G. Wolf, A. Bräuninger et al., “Induction and down-regulation of PLK, a human serine/threonine kinase expressed in proliferating cells and tumors,” Proceedings of the National Academy of Sciences, vol. 91, no. 5, pp. 1736–1740, 1994. View at Google Scholar
  24. R. Lake and W. Jelinek, “Cell cycle- and terminal differentiation-associated regula-tion of the mouse mRNA encoding a conserved mitotic protein kinase,” Molecular and Cellular Biology, vol. 13, no. 12, pp. 7793–7801, 1993. View at Google Scholar
  25. J. R. Jackson, D. R. Patrick, M. M. Dar, and P. S. Huang, “Targeted anti-mitotic therapies: can we improve on tubulin agents?” Nature Reviews Cancer, vol. 7, no. 2, pp. 107–117, 2007. View at Publisher · View at Google Scholar · View at Scopus
  26. K. Strebhardt and A. Ullrich, “Paul Ehrlich's magic bullet concept: 100 years of progress,” Nature Reviews Cancer, vol. 8, no. 6, pp. 473–480, 2008. View at Publisher · View at Google Scholar · View at Scopus
  27. K. Mross, A. Frost, S. Steinbild et al., “Phase I dose escalation and pharmacokinetic study of BI 2536, a novel polo-like kinase 1 inhibitor, in patients with advanced solid tumors,” Journal of Clinical Oncology, vol. 26, no. 34, pp. 5511–5517, 2008. View at Publisher · View at Google Scholar · View at Scopus
  28. J. Pawel von, M. Reck, W. Digel et al., “Random-ized phase II trial of two dosing schedules of BI, 2536, a novel Plk-1 inhibitor, in patients with relapsed advanced or metastatic non-small-cell lung cancer (NSCLC),” in ASCO Meeting Abstracts, abstract no. 8030, 2008. View at Google Scholar
  29. R. Evans, G. Dueck, R. Sidhu et al., “Expression, adverse prognostic significance and therapeutic small molecule inhibition of Polo-like kinase 1 in multiple myeloma,” Leukemia Research, vol. 35, no. 12, pp. 1637–1643, 2011. View at Publisher · View at Google Scholar
  30. M. Raab, S. Kappel, A. Krämer et al., “Toxicity modeling of Plk1-targeted therapies in genetically engineered mice and cultured primary mammalian cells,” Nature Communications, vol. 2, article 395, 2011. View at Publisher · View at Google Scholar
  31. M. Steegmaier, M. Hoffmann, A. Baum et al., “BI 2536, a ootent and selective inhibitor of polo-like kinase 1, inhibits tumor growth in vivo,” Current Biology, vol. 17, no. 4, pp. 316–322, 2007. View at Publisher · View at Google Scholar · View at Scopus
  32. G. V. Hegde, C. M. Munger, K. Emanuel et al., “Targeting of sonic hedgehog-GLI signaling: a potential strategy to improve therapy for mantle cell lymphoma,” Molecular Cancer Therapeutics, vol. 7, no. 6, pp. 1450–1460, 2008. View at Publisher · View at Google Scholar · View at Scopus