Research Article
FoxP3-Positive T-Regulatory Cells in Lymph Nodes with Mycosis Fungoides and Sézary Syndrome
Table 4
Flow cytometry, immunohistochemistry, and T-cell clonality results from lymph nodes.
| | Clinical diagnosis | DL ( = 15) | CTCL ( = 11) | value |
| | MF (PT/PQ/T) | 3/4/3 | 1/0/2 | 0.720 | | E-CTCL (EMF/NOS/SS) | 1/4/0 | 0/1/7 | 0.005 |
| | CD3 | ( = 13) | ( = 11) | 0.772 | | | 70 (46–94) | 67 (24–96) | | CD4 | ( = 13) | ( = 11) | 0.098 | | | 55 (21–81) | 66 (15–98) | | CD8 | ( = 13) | ( = 11) | 0.210 | | | 8 (2–16) | 5 (2–23) | | CD4/8 | ( = 13) | ( = 11) | 0.173 | | | 6.8 (2.4–34.5) | 8.8 (2.7–49.0) | | CD7 | ( = 13) | ( = 10) | 0.154 | | | 50 (28–82) | 34 (10–93) | | CD4/7 | ( = 13) | ( = 10) | 0.035 | | | 1.0 (0.4–2.5) | 1.7 (0.9–8.8) | | CD3/7 | ( = 13) | ( = 10) | 0.172 | | | 1.2 (0.9–2.6) | 2.1 (1.0–9.0) | | CD25 | ( = 12) | ( = 9) | 0.593 | | | 9 (2–34) | 7 (0.1–34) | | FoxP3 + (cells/mm3) |
( = 15) |
( = 11) | <0.001 | | | 99 (64–257) | 32 (0–189) | | T-cell clonality | 5 (33) | 8 (73) | 0.111 |
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E: erythrodermic; CTCL: cutaneous T-cell lymphoma; MF: mycosis fungoides; SS: Sézary syndrome; NOS: not otherwise specified; patch (PT), plaque (PQ), and tumor (T) phases.
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