Table of Contents
Metal-Based Drugs
Volume 1 (1994), Issue 2-3, Pages 221-231
http://dx.doi.org/10.1155/MBD.1994.221

Transition and Group IIB Metal Complexes With “Active Aldehyde” Derivatives of Thiamine

1Technological Institution of Athens, Department of Chemistry, Physics and Materials Technology, Agiou Spyridonos and Pallikaridi, Egaleo, Athens, Greece
2University of Ioannina, Department of Chemistry, Laboratory of Inorganic and General Chemistry, Ioannina 45-110, Greece
3Laboratoire de Chimie de Coordination du CNRS, 205 Route de Narbonne, Toulouse Cedex F-31077, France
4University of Southern California, Department of Chemistry, California 90089-1062, Los Angeles, USA

Received 1 June 1993

Copyright © 1994 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The Zn2+, Cd2+, Hg2+, Co2+ and Ni2+ ions produce zwitterionic type complexes with the ligands (L), 2-(α-hydroxy-benzyl)thiamine=HBT and 2-(α-hydroxy-cyclohexyl-methyl)thiamine = HCMT, of the type MLCl3. The ligands are in the S conformation, the metals are bound to N1, of the pyrimidine moiety of thiamine and the complexes have a trigonally distorted tetrahedral structure, as the crystal structure of the complex Zn(HCMT)Cl3 (orthorombic, a=14.4 b=14.1 c=17.4 β=105.6O V=3392A3 R=13.8%), the one and two dimensional H1 nmr spectra of the Zn2+, Cd2+ and Hg2+ complexes and the electronic spectra of the Co2+ and Ni2+ complexes show. A brief review of the previous techniques (structure of the Hg(HBT)Cl3 complex, IR-Raman spectra, C13 nmr in solution and solid state etc) used to characterize these complexes, is also given here and the proper conclusions drawn.