Table of Contents
Metal-Based Drugs
Volume 1 (1994), Issue 4, Pages 291-297
http://dx.doi.org/10.1155/MBD.1994.291a

Antitumor Organometallics. IV. The Mutagenic Potential of Some Diphenylantimony(III) Dithiophosphorus Derivatives

1Department of Chemistry and Biochemistry, University of Agricultural Sciences, Cluj-Napoca, Romania
2Chemistry Department, "Babes-Bolyai" University, Cluj-Napoca RO-3400, Romania
3Oncology Institute of Cluj-Napoca, Cluj-Napoca, Romania

Received 27 October 1993; Accepted 10 January 1994

Copyright © 1994 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Two diphenylantimony(III) derivatives of dithiophosphorus ligands, i.e. Ph2SbS2PPh2 and Ph2SbS2P(OPr-i)2, which were previously found to exhibit antitumor properties, have been now investigated for potential mutagenic effects in healthy and Ehrlich ascites tumor-bearing mice. Two short-term tests, i.e. the micronucleus test and the cytogenetic analysis, were used as end-points for mutagenicity. The results are consistent with a mutagenic potential for both organoantimony(III) compounds tested, the effect being higher for the phosphorodithioato derivative.