Table of Contents
Metal-Based Drugs
Volume 1 (1994), Issue 4, Pages 329-336

The Hypolipidemic Activity of Metal Complexes of Amine Carboxyboranes in Rodents

1Division of Medicinal Chemistry and Natural Products, School of Pharmacy, C.B. 7360, University of North Carolina, Chapel Hill 27559-7360, N.C., USA
2Boron Biologicals, Inc., 533 Pylon Dr. Raleigh, 27606, N.C., USA
3Department of Chemistry and Biochemistry, Utah State University, Logan 84322, Utah, USA

Received 9 September 1993; Accepted 10 October 1993

Copyright © 1994 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The metal complexes of amine-carboxyborane including copper, chromium, zinc, calcium amd cobalt were effective hypolipidemic agents lowering both serum cholesterol and triglyceride levels significantly in mice at 8 mg/kg/day, I.P. after 16 days. The agents reduced acetyl CoA synthetase, ATP-dependent citrate lyase, acyl CoA cholesterol acyl transferase, sn¯-glycerol-3-phosphate acyl transferase activities of rat liver and small intestinal mucosa after 14 days treatment. The neutral cholesterol ester hydrolase activity was elevated by the agents in both tissues. The metal complexes altered lipid levels in the bile of rats after treatment as well as the bile acid composition after 14 days administration, orally. The agents blocked enterohepatic absorption of cholesterol from rat isolated intestinal loops.