Table of Contents
Metal-Based Drugs
Volume 1 (1994), Issue 4, Pages 299-304
http://dx.doi.org/10.1155/MBD.1994.299

In Vitro Antitumour Activity of Some Triorganophosphinegold(I) Thionucleobases

1Department of Chemistry, The University of Adelaide, Adelaide 5005, South Australia, Australia
2Experimental Chemotherapy and Pharmacology Unit, Peter MacCallum Cancer Institute, 481 Little Lonsdale Street, Melbourne 3000, Victoria, Australia

Received 17 January 1994; Accepted 24 February 1994

Copyright © 1994 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A series of phosphinegold(I) thionucleobase analogues, [R3PAu(SRx)] (R = Et, Ph or chexyl; HSR1 = 2-mercaptobenzoic acid, HSR2 = 2-thiouracil, HSR3 = 6-mercaptopurine and HSR4 = 6-thioguanine) have been examined for their in vitro cytotoxicity in L1210 murine leukemia cells in culture. The range of ID50 values (continuous 48 h exposure) for the complexes is 0.041 - 0.131 μM. The complexes with SR3 and SR4 are generally the most active; however, there is no clear trend associated with the phosphine ligands.