Table of Contents
Metal-Based Drugs
Volume 1, Issue 2-3, Pages 195-200
http://dx.doi.org/10.1155/MBD.1994.195

Monofunctional and Interstrand DNA Adducts of Platinum(II) Complexes

Institute of Biophysics, Academy of Sciences of the Czech Republic, Kralovopolska 135, Brno 612 65, Czech Republic

Received 20 September 1993

Copyright © 1994 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The effects produced in DNA by monofunctional or interstrand adducts of platinum(II) complexes have been summarized. The monofunctional adducts destabilize DNA in a sequence-dependent manner via conformational distortions, which may have a denaturational character. It has been suggested that this conformational alteration facilitates in DNA the formation of the bidentate DNA adducts, whose formation is associated with a permanent or transient local denaturation. In addition, DNA interstrand cross-linking by cis-diamminedichloroplatinum(II) and its trans isomer produce in DNA lesions that have quite different characteristics. It has been suggested that these differences may have relevance to the distinct antitumor efficacy of the two platinum isomers.