Table of Contents
Metal-Based Drugs
Volume 1 (1994), Issue 2-3, Pages 247-264
http://dx.doi.org/10.1155/MBD.1994.247

Chelating Tendencies of Bioactive Aminophosphonates

1Department of Inorganic and Analytical Chemistry, Kossuth Lajos University, P.O. Box 21, Debrecen H -4010, Hungary
2Institute of Organic and Physical Chemistry, Technical University, Wroclaw PL 50 370, Poland

Received 3 September 1993

Copyright © 1994 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The metal-binding abilities of a wide variety of bioactive aminophosphonates, from the simple aminoethanephosphonic acids to the rather large macrocyclic polyaza derivatives, are discussed with special emphasis on a comparison of the analogous carboxylic acid and phosphonic acid systems. Examples are given of the biological importance of metal ion – aminophosphonate interactions in living systems, and also of their actual and potential applicability in medicine.