Table of Contents
Metal-Based Drugs
Volume 2, Issue 3, Pages 137-141

UVA-Photosensitivity of cis-Diamminedichloro-Platinum(II)-Modified DNA

Centre de Biophysique Moléculaire, CNRS, 1A, avenue dela Recherche Scientifique, Orléans cedex 2 F-45071, France

Received 20 January 1995; Accepted 16 February 1995

Copyright © 1995 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


cis-Diamminedichloroplatinum(II)-modified oligonucleotides contain-ing either a single intrastrand cross-link at the d(GpG) site or an interstrand cross-link at the d(GpC/GpC) site, were irradiated with 320 to 400-nm light. Upon irradiation, the adducts are photosensitive. Among the photo-induced reactions, the cleavage of the coordination bonds between platinum and the G residues in the interstrand cross-link is demonstrated.