Orla M. Ni Dhubhghaill, Peter J. Sadler, Esther Garcia Fernandez, "Cytotoxic Phosphinoarsino and Diphosphino Pd(II) Complexes of Thiolate Amino Acids and Glutathione", Metal-Based Drugs, vol. 2, Article ID 504726, 17 pages, 1995. https://doi.org/10.1155/MBD.1995.19
Cytotoxic Phosphinoarsino and Diphosphino Pd(II) Complexes of Thiolate Amino Acids and Glutathione
The novel complexes [Pd(L-L′)(SR)Cl] where L-L′ is (dppe) or (dadpe) and RSH is glutathione, L-cysteine, or N-acetyl-L-cysteine, have been prepared and characterised. Their structures in the solid-state and in solution are discussed. The introduction of cysteine or glutathione as a ligand in these complexes greatly improved their aqueous solubility compared with the hydrophobic parent dichloro complexes. The cytotoxicities of the glutathione complexes towards the cell-lines L1210, ADJ/PC6 and CH1 were investigated. Their cytotoxicities towards L1210 cells were comparable to those of the parent dichloro complexes.
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