Metal-Based Drugs

Metal-Based Drugs / 1995 / Article

Open Access

Volume 2 |Article ID 504726 |

Orla M. Ni Dhubhghaill, Peter J. Sadler, Esther Garcia Fernandez, "Cytotoxic Phosphinoarsino and Diphosphino Pd(II) Complexes of Thiolate Amino Acids and Glutathione", Metal-Based Drugs, vol. 2, Article ID 504726, 17 pages, 1995.

Cytotoxic Phosphinoarsino and Diphosphino Pd(II) Complexes of Thiolate Amino Acids and Glutathione

Received06 Jun 1994
Accepted23 Jun 1994


The novel complexes [Pd(L-L′)(SR)Cl] where L-L′ is Ph2PCH2CH2PPh2 (dppe) or Ph2AsCH2CH2PPh2 (dadpe) and RSH is glutathione, L-cysteine, or N-acetyl-L-cysteine, have been prepared and characterised. Their structures in the solid-state and in solution are discussed. The introduction of cysteine or glutathione as a ligand in these complexes greatly improved their aqueous solubility compared with the hydrophobic parent dichloro complexes. The cytotoxicities of the glutathione complexes towards the cell-lines L1210, ADJ/PC6 and CH1 were investigated. Their cytotoxicities towards L1210 cells were comparable to those of the parent dichloro complexes.

Copyright © 1995 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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