Table of Contents
Metal-Based Drugs
Volume 2, Issue 1, Pages 19-35

Cytotoxic Phosphinoarsino and Diphosphino Pd(II) Complexes of Thiolate Amino Acids and Glutathione

1Department of Chemistry, Birkbeck College, University of London, Gordon House, 29 Gordon Square, London WC1H OPP, United Kingdom
2Department of Inorganic Chemistry, University of Santiago de Compostela, Campus Universitario, Santiago de Compostela E-15706, Spain

Received 6 June 1994; Accepted 23 June 1994

Copyright © 1995 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The novel complexes [Pd(L-L′)(SR)Cl] where L-L′ is Ph2PCH2CH2PPh2 (dppe) or Ph2AsCH2CH2PPh2 (dadpe) and RSH is glutathione, L-cysteine, or N-acetyl-L-cysteine, have been prepared and characterised. Their structures in the solid-state and in solution are discussed. The introduction of cysteine or glutathione as a ligand in these complexes greatly improved their aqueous solubility compared with the hydrophobic parent dichloro complexes. The cytotoxicities of the glutathione complexes towards the cell-lines L1210, ADJ/PC6 and CH1 were investigated. Their cytotoxicities towards L1210 cells were comparable to those of the parent dichloro complexes.