Twelve new organotin(IV) complexes of the type RnSnLm
[where n = 3, m = 1, R = CH3
or
C6H5 ;
n = 2, m = 2, R = C6H5 or C4H9 ; L = anion of Schiff bases derived from the condensation
of 2-amino-5-(o
-anisyl)-l,3,4-thiadiazole with salicylaldehyde (HL-1), 2-
hydroxynaphthaldehyde (HL-2) and 2-hydroxyacetophenone (HL-3)] have been synthesized and
characterized by elemental analysis, molar conductances, electronic, infrared, far-infrared, H1
NMR
and S119n
Mössbauer spectral studies. Thermal studies of two complexes, viz., Ph3Sn
(L-1) and
Ph2Sn(L-2)2
have been carried out in the temperature range 25-1000∘C
using TG, DTG and DTA
techniques. All these complexes decompose gradually with the formation of SnO2
as an end product.
In vitro antimicrobial activity of the Schiff bases and their complexes has also been determined
against Streptococcus faecalis, Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa,
Staphylococcus aureus Penicillin resistance (2500 units), Candida albicans, Cryptococcus
neoformans, Sporotrichum schenckii, Trichophyton mentagrophytes and Aspergillus fumigatus. The
Schiff bases (HL-1), (HL-2) and the organotin(IV) compounds have also been tested against various
important herbicidal, fungicidal, insecticidal species and also for parasitological activity against
freeliving nematode.
