Metal-Based Drugs

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Volume 2 |Article ID 543649 | 9 pages | https://doi.org/10.1155/MBD.1995.211

Synthesis, Structure and Antitumour Properties of a New 1,2-Propylenediaminetetraacetate-Ruthenium(III) Compound

R. Vilaplana,1 M. A. Romero,2 M. Quirós,2 J. M. Salas,2 and F. González-Vílchez1

1Dpto. de Quífmica Inorgánica, F. de Química, Universidad de Sevilla, Spain

2Dpto. de Quífmica Inorgánica, F. de Química, Universidad de Granada, Spain

Received02 May 1995
Accepted18 May 1995

Abstract

A novel complex formed by ruthenium (III) and the sequestering ligand 1,2-propylenediaminetetraacetic acid (PDTA) has been synthetized and characterized. The structure of the monomeric compound, studied by X-ray diffraction , shows an almost symmetric octahedral geometry around the metal ion, with two chlorine atoms in a cis conformation. The antitumour activity against a variety of murine and human cancers is reported.

Copyright © 1995 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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