Metal-Based Drugs

Metal-Based Drugs / 1995 / Article

Open Access

Volume 2 |Article ID 584067 | https://doi.org/10.1155/MBD.1995.327

Claudiu T. Supuran, "Thienothiopyransulfonamides as Complexing Agents for the Preparation of Dual Carbonic Anhydrase Inhibitors", Metal-Based Drugs, vol. 2, Article ID 584067, 4 pages, 1995. https://doi.org/10.1155/MBD.1995.327

Thienothiopyransulfonamides as Complexing Agents for the Preparation of Dual Carbonic Anhydrase Inhibitors

Received26 Sep 1995
Accepted26 Oct 1995

Abstract

Co(II); Zn(II) and Cu(II) complexes of two new sulfonamide carbonic anhydrase (CA) inhibitors, derivatives of thienothiopyran-2-sulfonamide, were prepared and characterized by analytic, spectroscopic, magnetic and conductimetric measurements. The new complexes are more potent CA inhibitors than the parent sulfonamides, with IC50 values around 0.1 nM, against isozyme CA II.

Copyright © 1995 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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