The present article attempts to summarise the elements of the
mechanism of action of the antitumor drug cis¯-Platin presented the last few
years. Highlights on the discovery, of the drug and the development of it’s
second generation derivatives are presented, as well as the ways that
cis¯-DDP reacts with biomolecules as DNA and proteins and their models e.g.
nucleosides, nucleotides. Also the hydrolysis data are presented for
cis¯-DDP and its’ inactive congener trans¯-DDP, as well as for the second
generation drug carboplatin. Finally, usefull conclusions are given from
this work, pointing out the unanswered questions about the action of cis¯-DDP as well as its differences in action, in comparison with trans¯-DDP.