On the Mechanism of Action of the Antitumor Drug
( cis-DDP) and its Second Generation Derivatives
The present article attempts to summarise the elements of the mechanism of action of the antitumor drug -Platin presented the last few years. Highlights on the discovery, of the drug and the development of it’s second generation derivatives are presented, as well as the ways that -DDP reacts with biomolecules as DNA and proteins and their models e.g. nucleosides, nucleotides. Also the hydrolysis data are presented for -DDP and its’ inactive congener -DDP, as well as for the second generation drug carboplatin. Finally, usefull conclusions are given from this work, pointing out the unanswered questions about the action of -DDP as well as its differences in action, in comparison with -DDP.
Copyright © 1995 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.