Metal-Based Drugs

Metal-Based Drugs / 1995 / Article

Open Access

Volume 2 |Article ID 747132 |

Vasilis Aletras, Denis Hadjiliadis, Nick Hadjiliadis, "On the Mechanism of Action of the Antitumor Drug cis-Platin (cis-DDP) and its Second Generation Derivatives", Metal-Based Drugs, vol. 2, Article ID 747132, 33 pages, 1995.

On the Mechanism of Action of the Antitumor Drug cis-Platin (cis-DDP) and its Second Generation Derivatives

Received08 Feb 1995
Accepted20 Feb 1995


The present article attempts to summarise the elements of the mechanism of action of the antitumor drug cis¯-Platin presented the last few years. Highlights on the discovery, of the drug and the development of it’s second generation derivatives are presented, as well as the ways that cis¯-DDP reacts with biomolecules as DNA and proteins and their models e.g. nucleosides, nucleotides. Also the hydrolysis data are presented for cis¯-DDP and its’ inactive congener trans¯-DDP, as well as for the second generation drug carboplatin. Finally, usefull conclusions are given from this work, pointing out the unanswered questions about the action of cis¯-DDP as well as its differences in action, in comparison with trans¯-DDP.

Copyright © 1995 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Related articles

No related content is available yet for this article.
 PDF Download Citation Citation
 Order printed copiesOrder

Article of the Year Award: Outstanding research contributions of 2021, as selected by our Chief Editors. Read the winning articles.