The new potential tracer of bone imaging, AHBDP-Sn(II)-TcO.3H2O
was synthesized by
reducing the TcO4−
to TcO2+
in the presence of AHBDP and Sn(ll)’s reducing agent. We found that
tin rapidly forms a stable complex with AHBDP, giving AHBDP-Sn(II).3H2O. In the excess of AHBDP-Sn(ll).3H2O, the AHBDP-Sn(II).3H2O coordinates with TcO2+ to give AHBDP-Sn(II)-TcO.3H2O
which could polymerise or oligomerise to give hydrophobic species. The overall process appears as
a first-order reaction (K= 0.67 ± 0.005s−1). In rats, the fixation of AHBDP-Sn(II)-99m
TcO. 3H2O on
bone is homogeneous and the scintigraphic images have the same quality as those of
1-hydroxymethane-1,1-diphosphonate-Technetium (HMDP-99mTc). The activity in non-target
organs was neglible.