Abstract
Coordination compounds of Co(II), Ni(II), Cu(II), Zn(II), and Cd(II) with 1,3,4-thiadiazole-2,5-disulfonamide as ligand were synthesized and characterized by IR and UV spectroscopy, conductimetry and
thermogravimetry. The parent ligand is a very weak carbonic anhydrase (CA) inhibitor, although it
constituted the lead for developing important classes of diuretics. The complex derivatives behave as much
stronger CA inhibitors, with