Table of Contents
Metal-Based Drugs
Volume 3, Issue 4, Pages 173-183

The Hypolipidemic Activity of Boronated Nucleosides in Male Mice and Rats

1Division of Medicinal Chemistry and Natural Products, School of Pharrnacy, University of North Carolina, Chapel Hill 27599-7360, North Carolina, USA
2Boron Biologicals, Inc., 620 Hutton St., Raleigh 27606, NC, USA

Received 24 June 1996; Accepted 8 July 1996

Copyright © 1996 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The boronated nucleosides with varying bases and sugar moieties were shown to be potent hypolipidemic agents in rodents. The 3′– aminocynaoborane dideoxythymidine derivative caused reductions in serum cholesterol and triglyceride levels, tissue lipids, VLDL and LDL cholesterol levels while elevating HDL cholesterol levels in rodents. The agents suppressed rat hepatic acetyl CoA synthetase, HMG-CoA reductase, acyl-CoA cholesterol acyl transferase, phosphatidylate phosphohydrolase and lipoprotein lipase activities while elevating cholesterol-7α-hydroxylase activity from 25 to 100 μM.