Effect of Complexes of Cobalt With Aminoacids on the Replication
of Herpes Simplex Virus Type 1 (HSV-1)

Varadinova, T.; Shishkov, S.; Panteva, M.; Bontchev, P.

doi:https://doi.org/10.1155/MBD.1996.149

Metal-Based Drugs

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Volume 3 |Article ID 354247 | https://doi.org/10.1155/MBD.1996.149

T. Varadinova, S. Shishkov, M. Panteva, P. Bontchev, "Effect of Complexes of Cobalt With Aminoacids on the Replication of Herpes Simplex Virus Type 1 (HSV-1)", Metal-Based Drugs, vol. 3, Article ID 354247, 6 pages, 1996. https://doi.org/10.1155/MBD.1996.149

Effect of Complexes of Cobalt With Aminoacids on the Replication of Herpes Simplex Virus Type 1 (HSV-1)

T. Varadinova,¹ S. Shishkov,¹ M. Panteva,¹ and P. Bontchev²

¹Laboratory of Virology, Faculty of Biology, Sofia University, 8 Dragan Tzankov Blvd 1, Bulgaria

²Faculty of Chemistry, Sofia University, 8 Dragan Tzankov Blvd 1, Bulgaria

Received29 Feb 1996

Accepted22 Mar 1996

Abstract

Cobalt, being essential metal, influences different physiological and enzymatic functions. As cobalt does not accumulate in the body, Co-compounds have relatively low toxicity. The aim of the present study is the effect of complexes of Co(II) with aminoacids - lysine, arginine, histidine and serine on HSV-1 replication. No effect of [O2Co(his)4].nH2O and [O2Co(arg)2].nH2O on HSV-1 infection in vitro was found. Both, [O2Co(lys)2].nH2O and [O2Co(ser)2].nH2O suppress the attachement of HSV-1 particles onto target cells and the viral replication as well. Moreover, the properties of the particular Co-complex (charge, stability, structure) are manifestated by their virucidal effect. Thus, [O2Co(ser)2].nH2O irreversibly inhibits the infectious activity of free HSV-1 virions, while virucidal effect of [O2Co(lys)2].nH2O is completely reversible after the 2h of contact.

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Copyright © 1996 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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