Metal-Based Drugs

PDF
Metal-Based Drugs / 1996 / Article

On this page

AbstractCopyright

Open Access

Volume 3 |Article ID 354247 | 6 pages | https://doi.org/10.1155/MBD.1996.149

Effect of Complexes of Cobalt With Aminoacids on the Replication of Herpes Simplex Virus Type 1 (HSV-1)

T. Varadinova,1 S. Shishkov,1 M. Panteva,1 and P. Bontchev2

1Laboratory of Virology, Faculty of Biology, Sofia University, 8 Dragan Tzankov Blvd 1, Bulgaria

2Faculty of Chemistry, Sofia University, 8 Dragan Tzankov Blvd 1, Bulgaria

Received29 Feb 1996
Accepted22 Mar 1996

Abstract

Cobalt, being essential metal, influences different physiological and enzymatic functions. As cobalt does not accumulate in the body, Co-compounds have relatively low toxicity. The aim of the present study is the effect of complexes of Co(II) with aminoacids - lysine, arginine, histidine and serine on HSV-1 replication. No effect of [O2Co(his)4].nH2O and [O2Co(arg)2].nH2O on HSV-1 infection in vitro was found. Both, [O2Co(lys)2].nH2O and [O2Co(ser)2].nH2O suppress the attachement of HSV-1 particles onto target cells and the viral replication as well. Moreover, the properties of the particular Co-complex (charge, stability, structure) are manifestated by their virucidal effect. Thus, [O2Co(ser)2].nH2O irreversibly inhibits the infectious activity of free HSV-1 virions, while virucidal effect of [O2Co(lys)2].nH2O is completely reversible after the 2h of contact.

Copyright © 1996 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

More related articles

42 Views | 70 Downloads | 2 Citations
PDF Download Citation Citation
Order printed copiesOrder

Related articles

We are committed to sharing findings related to COVID-19 as quickly and safely as possible. Any author submitting a COVID-19 paper should notify us at help@hindawi.com to ensure their research is fast-tracked and made available on a preprint server as soon as possible. We will be providing unlimited waivers of publication charges for accepted articles related to COVID-19. Sign up here as a reviewer to help fast-track new submissions.