Table of Contents
Metal-Based Drugs
Volume 3, Issue 2, Pages 75-78

Triphenyltin Ortho-Aminophenyl- and 2-Pyridyl-Thiolates: Synthesis and In Vitro Antitumour Activity

1Free University of Brussels V.U.B., Pleinlaan 2, Department of General and Organic Chemistry, Faculty of Applied Sciences, Brussels B-1050, Belgium
2Free University of Brussels V.U.B., Pleinlaan 2, High Resolution NMR Centre, Brussels B-1050, Belgium
3Department of Chemistry, The University of Adelaide, Adelaide 5005, S. A., Australia
4Medical Department, Pharmachemie BV, Haarlem NL-2003 RN, Netherlands Antilles

Received 18 January 1996; Accepted 27 February 1996

Copyright © 1996 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The synthesis, spectroscopic characterization and in vitro antitumour activity of two triorganotin compounds, triphenyltin ortho-aminophenylthiolate (1) and triphenyltin 2-pyridylthiolate, compound (2) are reported. The structure of 1 is confirmed by X-ray diffraction, with the tin atom in a distorted tetrahedral geometry because of monodentate coordination, as a thiolate (Sn-S 2.431(2) Å), of the ortho-aminophenylthiolate ligand. The in vitro antitumour activities of 1 and 2, against a number of cell lines, are comparable to those exhibited by methotrexate and doxorubicin, and higher than those of carboplatin and cisplatin.