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Metal-Based Drugs
Volume 4 (1997), Issue 2, Pages 57-63
http://dx.doi.org/10.1155/MBD.1997.57

Ternary Complexes of cis-(NH3)2PtCl2 (cis-DDP) With Guanosine (guo), Cytidine (cyd) and the Aminoacids Glycine (gly), L-Alanine (ala), L-2-Aminobutyric Acid (2-aba), L-Norvaline (nval) and L-Norleucine (nleu)

1Laboratory of Inorganic and General Chemistry, University of Ioannina, Ioannina 451 10, Greece
2Medical Faculty, Laboratory of Experimental Physiology, University of Ioannina, Ioannina 451 10, Greece

Received 3 February 1997; Accepted 5 March 1997

Copyright © 1997 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The ternary complexes of formulae cis-[(NH3)2Pt(nucl)(amac)]NO3, where nucl = guo and cyd (guanosine and cytidine) and amac = the deprotonated aminoacids glycine (gly), L-alanine (ala), L-2-aminobutyric acid (2-aba), L-norvaline (nval) and L-norleucine (nleu), were prepared from the reactions of the binary chelated ones cis-[(NH3)2Pt(amac)]NO3 with the nucleosides.

They were characterized by H1, C13 and Pt195 NMR and IR spectra, together with elemental analysis and conductivity measurements. The aminoacids coordinate with Pt(II) in the ternary complexes with their terminal -NH2 groups, guo through N7 and cyd through N3. Ligand-ligand hydrophobic interactions were also observed in the ternary complexes and were stronger with longer aliphatic chains of the aminoacids. The E3 sugar conformation increased by 5-7% in the ternary systems, as compared to the free nucleosides, while the percentage of the gg conformation remained almost constant and the one of the anti conformation of the sugar increased also slightly. Finally, the h conformer around the Cα-Cβ bonds of the aminoacids reached a maximum in the binary systems and decreased again considerably in the ternary ones.