Di-n-Butyl-, Tri-n-Butyl- and Triphenyltin dl-Terebates: Synthesis, Characterization and In Vitro Antitumour Activity

Gielen, Marcel; Ma, Huairang; Bouhdid, Abdeslam; Dalil, Hassan; Biesemans, Monique; Willem, Rudolph

doi:https://doi.org/10.1155/MBD.1997.193

Metal-Based Drugs

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Volume 4 |Article ID 564582 | https://doi.org/10.1155/MBD.1997.193

Marcel Gielen, Huairang Ma, Abdeslam Bouhdid, Hassan Dalil, Monique Biesemans, Rudolph Willem, "Di-n-Butyl-, Tri-n-Butyl- and Triphenyltin dl-Terebates: Synthesis, Characterization and In Vitro Antitumour Activity", Metal-Based Drugs, vol. 4, Article ID 564582, 5 pages, 1997. https://doi.org/10.1155/MBD.1997.193

Di-n-Butyl-, Tri-n-Butyl- and Triphenyltin dl-Terebates: Synthesis, Characterization and In Vitro Antitumour Activity

Marcel Gielen,¹ Huairang Ma,^1,3 Abdeslam Bouhdid,¹ Hassan Dalil,¹ Monique Biesemans,^1,2 and Rudolph Willem^1,2

¹Department of General and Organic Chemistry, Faculty of Applied Sciences, Free University of Brussels V.U.B., Pleinlaan 2, Belgium

²High Resolution NMR Centre, Free University of Brussels V.U.B., Pleinlaan 2, Belgium

³Department of Chemistry, Northwest University, ShaanXi, China

Received25 Apr 1997

Accepted06 May 1997

Abstract

Di-n-butyltin, tri-n-butyltin and triphenyltin terebates were screened against several human tumour cell lines and found comparably or more active than carboplatin, cis-platin, 5-fluorouracil, methotrexate and doxorubicin, some reference compounds used clinically.

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Copyright © 1997 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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