Metal-Based Drugs

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Metal-Based Drugs / 1997 / Article

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Volume 4 |Article ID 564582 | 5 pages | https://doi.org/10.1155/MBD.1997.193

Di-n-Butyl-, Tri-n-Butyl- and Triphenyltin dl-Terebates: Synthesis, Characterization and In Vitro Antitumour Activity

Marcel Gielen,1 Huairang Ma,1,3 Abdeslam Bouhdid,1 Hassan Dalil,1 Monique Biesemans,1,2 and Rudolph Willem1,2

1Department of General and Organic Chemistry, Faculty of Applied Sciences, Free University of Brussels V.U.B., Pleinlaan 2, Belgium

2High Resolution NMR Centre, Free University of Brussels V.U.B., Pleinlaan 2, Belgium

3Department of Chemistry, Northwest University, ShaanXi, China

Received25 Apr 1997
Accepted06 May 1997

Abstract

Di-n-butyltin, tri-n-butyltin and triphenyltin terebates were screened against several human tumour cell lines and found comparably or more active than carboplatin, cis-platin, 5-fluorouracil, methotrexate and doxorubicin, some reference compounds used clinically.

Copyright © 1997 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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