Table of Contents
Metal-Based Drugs
Volume 4, Issue 5, Pages 279-285
http://dx.doi.org/10.1155/MBD.1997.279

Naturally Occurring Hydroxy Napthoquinones and Their Iron Complexes as Modulators of Radiation Induced Lipid Peroxidation in Synaptosomes

1Department of Chemistry, University of Pune, Pune 4110 07, India
2Radiation Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110 067, India

Received 7 September 1997; Accepted 24 September 1997

Copyright © 1997 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The modulation of radiation induced lipid peroxidation in synaptosomes by iron (II) and iron (III) complexes of two naturally occurring and therapeutically relevant naphthoquinones viz. 5,hydroxy-1,4 naphthoquinone; juglone and 2,hydroxy-1,4 naphthoquinone; lawsone, have been studied. At lower concentrations the complexes enhance lipid peroxidation predominantly through redox cycling as observed for Fe(II)- juglonate while at higher concentrations the complexes tend to limit lipid peroxidation through fast recombinations.