Table of Contents
Metal-Based Drugs
Volume 6, Issue 3, Pages 169-175
http://dx.doi.org/10.1155/MBD.1999.169

Antioxidant and Prooxidant Effects of Metal Dafonates on the NADPH-Dependent Lipid Peroxidation in the Murine Hepatic Microsomal System

1Free Radical Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110 067, India
2Department of Chemistry, University of Pune, Pune 411 007, India

Received 21 April 1999; Accepted 11 May 1999

Copyright © 1999 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Dafone inhibits the lipid peroxidation significantly in a concentration dependent manner. The inhibition was found to be an uncompetitive type with the inhibition constant (Ki) of 62.5μM On the other hand complexation with metal ions results in a significant reversal from antioxidant to pro-oxidant properties for the resulting complexes which are cationic and with associated halometallate anions. The nature of the potentiation in case of the ferric compound was of competitive type with activation constant (Ka) having the value 32.5μM . The neutral copper-dafonate complex, however, inhibits lipid peroxidation with increase in concentration.