Table of Contents
Metal-Based Drugs
Volume 6 (1999), Issue 6, Pages 361-368

A Study of the Antitumour Activity of Four Triorganophosphinegold(I) Thiolates: R3PAu(SR), R = Ph, Cy, Et; SRH = 6-Mercaptopurine and R = Et; SRH = 6-Thioguanine

1AMRD Operations Pty Ltd, 576 Swan Street, Richmond 3121, Victoria, Australia
2Department of Chemistry, The University of Adelaide, Adelaide 5005, Australia

Received 4 October 1999; Accepted 12 October 1999

Copyright © 1999 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The antitumour activities of four triorganophosphinegold(I) thiolates, R3PAu(SR) [R = Ph, Cy, Et; SRH = 6-mercaptopurine and R Et; SRH = 6-thioguanine] against the National Cancer Institute (NCI) panel of 60 cell lines are reported The [Cy3PAu(6-MP)] complex proved to be the more cytotoxic of the four complexes tested. For the 6-MP series, an order of cytotoxicity was established such that the activity followed the order R = Cy > Ph > Et. Sub-panel selectivity against the Leukemia cell lines was found for each of [Cy3PAu(6-MP)] and [Et3PAu(6-TG)].