Table of Contents
Metal-Based Drugs
Volume 6 (1999), Issue 2, Pages 127-134

Radioprotectant Activity of Dicopper(II) Tetrakis(3,5- Diisopropylsalicylate) and Manganese(II) bis(3,5- Diisopropylsalicylate) Alone and in Combination

1University of Arkansas for Medical Sciences Campus, Division of Medicinal Chemistry, College of Pharmacy, Little Rock 72205, Arkansas, USA
2University of Arkansas for Medical Sciences Campus, Arkansas Cancer Research Center, Little Rock 72205, Arkansas, USA
3Research Center, University of Arkansas at Pine Bluff, Pine Bluff 71601, Arkansas, USA

Received 15 March 1999; Accepted 31 March 1999

Copyright © 1999 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Dicopper(ll) tetrakis(3,5-diisopropylsalicylate), (Cu(II)2(3,5-DIPS)4, manganese(II) bis(3,5-diisopropylsalicylate), Mn(II)(3,5-DIPS)2 or combinations of them were used to treat gamma-irradIated mice in examining the possibility that combination treatments might be more effective in increasing survival than treatment with either complex alone. Doses of 0, 10, 20, or 40 μmol of each complex per kilogram of body mass were administered subcutaneously in a factorial design before 9 Gy gamna irradiation, an LD90 dose of irradiation. Doses of 0, 10, 20, or 40 μmolCu(II)2(3,5-DIPS)4 per kg of body mass produced 12, 28, 28, or 36 % survival, respectively, while doses of 0, 10, 20, or 40 μmolMn(II)(3,5-DIPS)2 per kg of body mass prduced 12, 36, 20, or 24 % survival, respectively. However, the combination of 20 μmolCu(II)2(3,5-DIPS)4 and 10 μmolMn(II)(3,5DIPS)2 produced the greatest survival, 48 %, which was 300 % greater than vehicle-treated mice (P=0.01). It is concluded that specific combination treatments can be used to maximize survival of lethally irradiated mice.