Table of Contents
Metal-Based Drugs
Volume 6 (1999), Issue 2, Pages 81-85

Synthesis, Spectroscopy and Electrochemistry of Fe(II) and Fe(III) Quinonemonooxime Complexes and Their DNA Cleaving Activities

1Department of Chemistry, University of Pune, Pune 411 007, India
2Department of Zoology, University of Pune, pune 411 007, India

Received 19 January 1999; Accepted 5 February 1999

Copyright © 1999 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Iron(II) and iron(III) complexes of 3,5-di-tert-butyl-o-benzoquinonemonooxime were synthesized and characterized by spectroscopic and electrochemical studies. Their ability to cleave DNA has been investigated under aerobic conditions at room temperature and in the presence and absence of H2O2 . The plasmid DNA pBR322 was effectively cleaved by these complexes in a concentration dependant manner.