Table of Contents
Metal-Based Drugs
Volume 6, Issue 1, Pages 19-24
http://dx.doi.org/10.1155/MBD.1999.19

Water Soluble Cyclophosphamide Adducts of Rhodium(II) Keto-Gluconate and Glucuronate. Synthesis, Characterization and In Vitro Cytostatic Assays

1Faculty of Pharmaceutical Sciences, University of São Paulo, SP 05389-970, Brazil
2Institute of Biomedical Sciences, Department of Pharmacology, University of São Paulo, SP, Brazil
3Institute of Chemistry, University of São Paulo, SP, Brazil

Received 8 December 1997; Accepted 6 January 1998

Copyright © 1999 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The synthesis, characterization and biological assays of two new rhodium carboxylate sugar derivatives and respective cyclosphosphamide adducts are described. The compounds, characterized by C13 and H1NMR , infrared and UV-visible spectra, presented high water solubility and hydration grades were confirmed given the concordance between thermal and CHN analyses. The adducts were active in vitro against K-562 cells.