Table of Contents
Metal-Based Drugs
Volume 7 (2000), Issue 1, Pages 49-54
http://dx.doi.org/10.1155/MBD.2000.49

Antifungal Activity of Ag(I) and Zn(II) Complexes of Sulfacetamide Derivatives

1Universitá degli Studi, Istituto di Clinica Dermosifilopatica, Centro MTS, Via degli Alfani 37, Firenze I-50122, Italy
2Universitá degli Studi, Dipartamento di Chimica, Laboratorio di Chimica Inorganica e Bioinorganica, Via Gino Capponi 7, Firenze I-50121, Italy

Received 3 December 1999; Accepted 27 January 2000

Copyright © 2000 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Reaction of sulfacetamide with arylsulfonyl isocyanates afforded a series of derivatives which were used as ligands (as conjugate bases) for the preparation of metal complexes containing Ag(I) and Zn(II). The newly synthesized complexes, unlike the free ligands, act as effective antifungal agents against Aspergillus and Candida spp., some of them showing activities comparable to ketoconazole, with minimum inhibitory concentrations in the range of 0.3 – 0.5 μg/mL. The mechanism of antifungal action of these complexes seems to be not connected with the inhibition of lanosterol-14-α-demethylase, since the levels of sterols assessed in the fungi cultures were equal in the absence or in the presence of the tested compounds. Probably the new complexes act as inhibitors of phosphomannose isomerase, a key enzyme in the biosynthesis of yeast cell walls.