Table of Contents
Metal-Based Drugs
Volume 7 (2000), Issue 4, Pages 177-183

Symmetric 1,1'-Dimethylferrocene-Derived Amino Acids: Their Synthesis, Characterization, Ligational and Biological Properties With Cu(II), Co(II) and Ni(II) Ions

Department of Chemistry, Islamia University, Bahawalpur, Pakistan

Received 28 July 2000; Accepted 11 September 2000

Copyright © 2000 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Some novel symmetric 1,1′-dimethylferrocene derived amino acids have been prepared by the reaction of 1,1′-ferrocenedimethyldichloride with amino acids (glycine, alanine, phenylalanine and tyrosine). Their Cu(II), Co(II) and Ni(II) complexes, of the type [M(L)] where [M = Cu(II) and L = L1-L5] and [M(L)Cl2] where [M-Co(II)and Ni(II), L = L1-L5] have been prepared. The dicarboxylic acids and their metal complexes were characterized by their physical, analytical and spectral data. The [M(L)] complexes showed a square planar geometry whereas an octahedral geometry was observed for [M(L)Cl2] complexes. The title dicarboxylic acids and their metal complexes have also been screened for their antibacterial activity.