Table of Contents
Metal-Based Drugs
Volume 8, Issue 4, Pages 215-234

Essential Metalloelement Chelates Facilitate Repair of Radiation Injury

1University of Arkansas, Medical Sciences Campus, Little Rock, Division of Medicinal Chemistry, Department of Pharmaceutical Sciences, College of Pharmacy, Arkansas 72205, USA
2University of Arkansas, Medical Sciences Campus, Little-Rock, Department of Microbiology and Immunology, College of Medicine, Arkansas 72205, USA
3National Health Research Institutes, Division of Environmental Health and Occupational Medicine Taiwan, China
4University of Arkansas at Pine Bluff, Department of Chemistry and Physics Pine Bluff, Arkansas 71611, USA

Received 7 December 2001; Accepted 20 December 2001

Copyright © 2001 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Treatment with essential metalloelement (Cu, Fe, Mn, and Zn) chelates or combinations of them before and/or after radiation injury is a useful approach to overcoming radiation injury. No other agents are known to increase survival when they are used to treat after irradiation, in a radiorecovery treatment paradigm. These chelates may be useful in facilitating de novo syntheses of essential metalloelement-dependent enzymes required to repair radiation injury. Reports of radioprotection, which involves treatment before irradiation, with calcium-channel blockers, acyl Melatonin homologs, and substituted anilines, which may serve as chelating agents after biochemical modification in vivo, as well as Curcumin, which is a chelating agent, have been included in this review. These inclusions are intended to suggest additional approaches to combination treatments that may be useful in facilitating radiation recovery. These approaches to radioprotection and radiorecovery offer promise in facilitating recovery from radiation-induced injury experienced by patients undergoing radiotherapy for neoplastic disease and by individuals who experience environmental, occupational, or accidental exposure to ultraviolet, x-ray, or γ-ray radiation. Since there are no existing treatments of radiation-injury intended to facilitate tissue repair, studies of essential metalloelement chelates and combinations of them, as well as combinations of them with existing organic radioprotectants, seem worthwhile.