Metal-Based Drugs

Metal-Based Drugs / 2001 / Article

Open Access

Volume 8 |Article ID 438269 | https://doi.org/10.1155/MBD.2001.85

Kira Rubina, Edgars Abele, Pavel Arsenyan, Ramona Abele, Maris Veveris, Edmunds Lukevics, "Synthesis of Silicon and Germanium Containing Heteroaromatic Sulfides as Cholesterol Level Lowering and Vasodilating Agents", Metal-Based Drugs, vol. 8, Article ID 438269, 9 pages, 2001. https://doi.org/10.1155/MBD.2001.85

Synthesis of Silicon and Germanium Containing Heteroaromatic Sulfides as Cholesterol Level Lowering and Vasodilating Agents

Abstract

Silicon and germanium containing heteroaromatic sulfides have been prepared using phase transfer catalytic (PTC) system thiol / Si or Ge containing alkyl halide / solid KOH / 18- crown-6 / toluene. The target sulfides were isolated in yields up to 92 %. It has been found that 2-{[dimethyl (β-triethylgermylethyl)-silylmethyl]thio}-1-methylimidazole and 2-{[dimethyl(β-triphenylsilylethyl) silyl-methyl]thio}benzothiazole are the most active cholesterol level lowering and vasodilating agents.

Copyright © 2001 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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