Table of Contents
Metal-Based Drugs
Volume 8, Issue 1, Pages 57-63
http://dx.doi.org/10.1155/MBD.2001.57

Synthesis, Characterization and Antiviral Properties of Pd(II) Complexes With Penciclovir

1Laboratory of Inorganic and General Chemistry, Department of Chemistry, University of Ioannina, Ioannina 45110, Greece
2Department of Chemistry, Physics and Material Technology, Technological Institution of Athens, Egaleo 12210, Greece
3National Institute of Chemistry, Hajdrihova 19, P.O.B. 3430, Ljubljana, Slovenia
4Katholieke Universiteit Leuven, Rega Institute for Medical Research, Minderbroedersstraat 10, Leuven B-3000, Belgium

Copyright © 2001 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

With the aim to improve and extend the antiviral activity of the antiherpic drug penciclovir, to a wider spectrum of viruses, we have synthesized and characterized new binary and ternary complexes of Pd(II) of formulae cis-(pen)2PdCl2 and cis,[(nucl)2Pd(pen)2]Cl2, where nucl = guanosine, inosine, cytidine or penciclovir. The characterization was mainly based on IR and H1 NMR spectroscopy, and the results showed that in all prepared complexes, penciclovir coordinates to the metal through N7. The far-i.r. spectrum of the complex cis-(pen)2PdCl2 confirmed the cis- geometry around Pd(II). All the prepared complexes were markedly active against HSV-1 and HSV-2 strains, but not against thymidine kinase-deficient HSV-1 strains.