Metal-Based Drugs

Metal-Based Drugs / 2001 / Article

Open Access

Volume 8 |Article ID 508385 |

Petia Genova, Tatiana Varadinova, Radostina Alexandrova, Sreco Trifunovic, Petar Radivojsa, "Cytotoxicity of Co(III) Complexes of Arginine ", Metal-Based Drugs, vol. 8, Article ID 508385, 4 pages, 2001.

Cytotoxicity of Co(III) Complexes of Arginine

Received10 Dec 2001
Accepted13 Dec 2001


The cytotoxicity of four Co(III) complexes of arginine on nontumour MDBK cells and on two cell lines derived from transplantable tumors, LSCC-SF(Mc29) and LSR-SF (SR), was evaluated comparative!y. Based on the cytotoxic concentration required to inhibit cell surveillance by 50% (CC50) it was found that: (i) the cytotoxicity of complexes tested increases when the concentration decreased; (ii) the cell surveillance depends on both complex and cell specificities. The complex specificity was illustrated by the order 1 > 4 > 23 . The cell specific response was demonstrated by the fact that LSCC-SG (Mc29) cells were up to 60 times more sensitive to 1 while LSR-SF (SR) cells were up to 1000 times more sensitive to 2 as compared to MDBK cells. Furthermore, with the prolongation of action on nontumour cells the cytotoxicity of 4 decreased up to 300 times while for both tumour cells it was independent on the duration of action.

Copyright © 2001 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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