Table of Contents
Metal-Based Drugs
Volume 8, Issue 4, Pages 195-198

Cytotoxicity of Co(III) Complexes of Arginine

1Laboratory of Virology, Faculty of Biology, Sofia University, 8 Dragan Tzankov Blvd., Sofia 1421, Bulgaria
2Institute of Experimental Pathology and Parasitology, Bulgarian Academy of Sciences, b1.25, Georgy Bonchev Blvd, Sofia 1113, Bulgaria
3Department of Chemistry, Faculty of Science, University of Kragujevac, 12 R. Domanovica, Kragujevac 3400, Serbia and Montenegro
4Faculty of Chemistry, Universityof Belgrade, Studentski trg.16, P.O.Box 158, , Belgrade 11000, Serbia and Montenegro

Received 10 December 2001; Accepted 13 December 2001

Copyright © 2001 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The cytotoxicity of four Co(III) complexes of arginine on nontumour MDBK cells and on two cell lines derived from transplantable tumors, LSCC-SF(Mc29) and LSR-SF (SR), was evaluated comparative!y. Based on the cytotoxic concentration required to inhibit cell surveillance by 50% (CC50) it was found that: (i) the cytotoxicity of complexes tested increases when the concentration decreased; (ii) the cell surveillance depends on both complex and cell specificities. The complex specificity was illustrated by the order 1 > 4 > 23 . The cell specific response was demonstrated by the fact that LSCC-SG (Mc29) cells were up to 60 times more sensitive to 1 while LSR-SF (SR) cells were up to 1000 times more sensitive to 2 as compared to MDBK cells. Furthermore, with the prolongation of action on nontumour cells the cytotoxicity of 4 decreased up to 300 times while for both tumour cells it was independent on the duration of action.